Nasal decongestant exposure in patients with pulmonary arterial hypertension: a pilot study

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Nasal decongestant exposure in patients with pulmonary arterial hypertension: a pilot study.

In the scientific and medical community, it is recognised that exposure to certain drugs could promote the development of pulmonary arterial hypertension (PAH). These drugs, with a “class effect” (amphetamine-like) or not (dasatinib), are prescribed for serious (dasatinib, interferons) or moderate (benfluorex) pathologies and do not induce PAH in all patients [1–9]. As a result, assessment of d...

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BACKGROUND Pulmonary microcirculation abnormalities are the main determinants of pulmonary arterial hypertension (PAH) pathophysiology. We hypothesized that PAH patients have peripheral tissue microcirculation alterations that might benefit from hyperoxic breathing. We evaluated peripheral muscle microcirculation with near-infrared spectroscopy, before and after hyperoxic breathing. METHODS E...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2015

ISSN: 0903-1936,1399-3003

DOI: 10.1183/13993003.00051-2015